Eye Information
Cataract
Cataract is where the clear lens inside your eye becomes cloudy, yellow or opaque.
CES cataract surgery information brochure
Cataract surgery for angle closure
Glaucoma
Glaucoma is accelerated loss of optic nerve fibres.
Neuro-ophthalmology
Neuro-ophthalmology refers to other optic nerve diseases and neurological conditions affecting the visual system.
Research Projects
This is a list of recent and ongoing projects at Capital Eye Specialists:
- ARTEMIS multinational trial of bimatoprost SR implants (compared to timolol eye drops). We are a participating centre. This trial is sponsored by Allergan.
- ATHENA multinational trial of bimatoprost SR implants (compared to SLT laser treatment). We are a participating centre. This trial is sponsored by Allergan.
- Timolol administration study, comparing methods of eye drops administration to reduce systemic side effects.
- Laser iridoplasty studies. Using high quality OCT imaging we have measured the changes in the anterior chamber with laser iridoplasty, exploring the mechanism and longevity of these effects.
- Open source pupilometer. This collaboration with Victoria University of Wellington schools of Design and Engineering has developed a new device for testing pupil reactions. The device both expands on the capability of standard devices and clinical testing, but also is made cheaply from commonly available components. Multiple future projects using the device are planned.
- Optic nerve head drusen. These common and benign deposits in the optic disc are poorly understood and raise interesting hypotheses about the physiology of the optic disc. We have conducted a review and published a brief study to explain the OCT findings.
- Eye movements as biomarkers of disease. Rapid eye movements are difficult to examine, but they can reveal information about the brain. We are developing cheaper ways to examine rapid eye movements as biomarkers.
- Mitochondrial copy number. This intriguing biomarker may be indicative of response to mitochondrial mutation or dysfunction, and might be modifiable by medications to reduce risk of vision loss in certain circumstances. A phase one trial is planned.
These are peer-reviewed publications of which Prof Wells or Dr Gale are authors:
Optic nerve head drusen: an update.
Palmer E, Gale J, Crowston JG, Wells AP.
Neuro-Ophthalmology 2018 [Epub ahead of print]
Management of trachoma in the Pacific: have we got it wrong?
Loveridge-Easther C, Murray N, Gale J.
Clin Exp Ophthalmol. 2018 [Epub ahead of print]
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.
Gharahkhani P, Burdon KP, Cooke Bailey JN, et al.
Sci Rep. 2018;8(1):3124.
Factors predicting the success of trabeculectomy bleb enhancement with needling.
Than JYL, Al-Mugheiry TS, Gale J, Martin KR.
Br J Ophthalmol. 2018 [Epub ahead of print]
Multimodal imaging of buried optic nerve head drusen.
Wang DD, Leong JCY, Gale J, Wells AP.
Eye (Lond). 2018;32(6):1145-1146
The enduring effect of laser iridoplasty.
Wong D, Gale J, Wells AP.
Clin Exp Ophthalmol. 2018 [Epub ahead of print]
Retinal slippage fold causing a matching contralateral scotoma.
Gale J, Small K.
J Clin Neurosci. 2017;42:111-113
Profound vision loss impairs psychological well-being in young and middle-aged individuals.
Garcia GA, Khoshnevis M, Gale J, Frousiakis SE, Hwang TJ, Poincenot L, Karanjia R, Baron D, Sadun AA.
Clin Ophthalmol. 2017;11:417-427
Natural History of Conversion of Leber’s Hereditary Optic Neuropathy: A Prospective Case Series.
Hwang TJ, Karanjia R, Moraes-Filho MN, Gale J, Tran JS, Chu ER, Salomao SR, Berezovsky A, Belfort R Jr, Moraes MN, Sadun F, DeNegri AM, La Morgia C, Barboni P, Ramos CDVF, Chicani CF, Quiros PA, Carelli V, Sadun AA.
Ophthalmology. 2017;124(6):843-850
An International Study of Emotional Response to Bilateral Vision Loss Using a Novel Graphical Online Assessment Tool.
Gale J, Khoshnevis M, Frousiakis SE, Karanjia R, Poincenot L, Sadun AA, Baron DA.
Psychosomatics. 2017;58(1):38-45
How safe is diode laser peripheral iridoplasty for the corneal endothelium?
Müller L, Reeves GM, Leong JC, Wells AP.
Clin Exp Ophthalmol. 2016;44(8):735-737
Spectral domain optical coherence tomography evidence on the mechanism of diode laser peripheral iridoplasty.
Stevenson C, Leong JC, Ang GS, Wells AP.
Clin Exp Ophthalmol. 2015;43(5):474-6
Anterior Segment Optical Coherence Tomography Changes to the Anterior Chamber Angle in the Short-term following Laser Peripheral Iridoplasty.
Yoong Leong JC, O’Connor J, Soon Ang G, Wells AP.
J Curr Glaucoma Pract. 2014;8(1):1-6
Statins can induce myasthenia gravis.
Gale J, Danesh-Meyer HV.
J Clin Neurosci. 2014;21(2):195-7
Repeatability of primary selective laser trabeculoplasty in patients with primary open-angle glaucoma.
Avery N, Ang GS, Nicholas S, Wells A.
Int Ophthalmol. 2013;33(5):501-6
Optometry-based general population survey of pupil ruff atrophy and ocular hypertension.
Ang GS, Stevenson PJ, Sargent G, Grimmer P, Corbett P, Jourdain E, Wells AP.
Clin Exp Ophthalmol. 2013;41(4):360-7
The New Zealand Vocational Trainee 2011 Survey: a national snapshot of vocational training.
Foo J, Gale J, Poynter M, Blackett J.
N Z Med J. 2013;126(1371):54-62.
Pupil ruff atrophy correlations with intraocular pressure and cup-to-disc ratio in a glaucoma clinic population.
Ang GS, Wong T, Nicholas S, Wells AP.
Ophthalmology. 2012 Aug;119(8):1546-51
Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study.
Chua BE, Nguyen DQ, Qin Q, Ruddle JB, Wells AP, Niyadurupola N, Gupta V, Wong TT, Coote MA, Crowston JG.
Clin Exp Ophthalmol. 2012 Nov;40(8):773-9
Comparison of a travoprost BAK-free formulation preserved with polyquaternium-1 with BAK-preserved travoprost in ocular hypertension or open-angle glaucoma.
Gandolfi S, Paredes T, Goldberg I, Coote M, Wells A, Volksone L, Pillai MR, Stalmans I, Denis P; Travoprost Bak-Free Clinical Study Group.
Eur J Ophthalmol. 2012;22(1):34-44
The effect of thin, thick, and normal corneas on Goldmann intraocular pressure measurements and correction formulae in individual eyes.
Park SJ, Ang GS, Nicholas S, Wells AP.
Ophthalmology. 2012 Mar;119(3):443-9
Novel grading system for pupillary ruff changes and associated features.
Wong T, Ang GS, Nicholas S, Wells AP.
Clin Exp Ophthalmol. 2012 Jul;40(5):440-7
Prospective study of surgical outcomes and bleb morphology using indocyanine green as a surgical dye in trabeculectomy with mitomycin C.
Chan KC, Ang GS, Birchall W, Wong T, Wakely L, Reeves GM, Small KM, Wells AP.
Clin Exp Ophthalmol. 2012;40(4):e143-8
Comparison of standard trabeculectomy versus microtrabeculectomy as a surgical treatment for glaucoma: a randomized clinical trial.
Ang GS, Chan KC, Poostchi A, Nicholas S, Birchall W, Wakely L, Wells AP.
Clin Exp Ophthalmol. 2011 Sep-Oct;39(7):648-57
Iridotomy in Caucasians: a more conventional angle.
Ang GS, Wells AP.
Clin Exp Ophthalmol. 2011 Aug;39(6):586-7
Factors influencing laser peripheral iridotomy outcomes in white eyes: an anterior segment optical coherence tomography study.
Ang GS, Wells AP.
J Glaucoma. 2011 Dec;20(9):577-83
Poor utility of intraocular pressure correction formulae in individual glaucoma and glaucoma suspect patients.
Ang GS, Nicholas S, Wells AP.
Clin Exp Ophthalmol. 2011 Mar;39(2):111-8
Optic disc area and correlation with central corneal thickness, corneal hysteresis and ocular pulse amplitude in glaucoma patients and controls.
Insull E, Nicholas S, Ang GS, Poostchi A, Chan K, Wells A.
Clin Exp Ophthalmol. 2010 Dec;38(9):839-44
Changes in Caucasian eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study.
Ang GS, Wells AP.
Clin Exp Ophthalmol. 2010 Nov;38(8):778-85
Goldmann applanation tonometry and dynamic contour tonometry after treatment with prostaglandin analog/prostamide.
Ang GS, Wells AP.
J Glaucoma. 2010 Jun-Jul;19(5):346
Pediatric Ahmed valves.
Ang GS, Crowston JG, Wells AP.
Ophthalmology. 2010 Jun;117(6):1277-8
Subconjunctival hemorrhage and conjunctivochalasis.
Nicholas S, Wells A.
Ophthalmology. 2010 Jun;117(6):1276-7
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma.
Poostchi A, Nicholas S, Wells AP.
Am J Ophthalmol. 2010 Mar;149(3):524-5
In vivo fluorescence mode confocal microscopy of subepithelial tissues in glaucoma filtering blebs.
Wells AP, Wakely L, Birchall W.
Ophthalmic Surg Lasers Imaging. 2010 Jan-Feb;41(1):78-82
Optic disc diameter increases during acute elevations of intraocular pressure.
Poostchi A, Wong T, Chan KC, Kedzlie L, Sachdev N, Nicholas S, Garway-Heath DF, Wells AP.
Invest Ophthalmol Vis Sci. 2010 May;51(5):2313-6
The iCare rebound tonometer: comparisons with Goldmann tonometry, and influence of central corneal thickness.
Poostchi A, Mitchell R, Nicholas S, Purdie G, Wells A.
Clin Exp Ophthalmol. 2009 Sep;37(7):687-91
Comparison of fibrin glue with sutures for pterygium excision surgery with conjunctival autografts.
Hall RC, Logan AJ, Wells AP.
Clin Exp Ophthalmol. 2009 Aug;37(6):584-9
Effects of exercise on ocular physiology and disease.
Gale J, Wells AP, Wilson G.
Surv Ophthalmol. 2009;54(3):349-55